Química Nova · 2014 · 10 citations · 0 references
PharmacyPharmaceutical AnalysisPharmaceuticsControlled Release FormulationsDrug DeliveryTransdermal Drug DeliveryGonadal Steroid HormonesLiposomal FormulationsLiposome-based DeliveryTransdermal Controlled Release SystemsTransdermal Dosage FormsTransdermal FormulationsDrug-loaded EmulsionsEmulsion-based Delivery SystemsEmulsionsHigh-performance Liquid ChromatographyLiposomal NanocarriersSex Steroid PhysiologyTransdermal Delivery SystemsTransdermal Drug Delivery Systems
In vitro release of bioidentical hormones in four different liposomal transdermal emulsions (containing testosterone, progesterone, estradiol, or estradiol and estriol) was assessed. For this purpose, novel high-performance liquid chromatography methods were developed and validated in an eco-friendly manner and used to determine the in vitro release of such products. The methods were suitable for our intended goal, and the emulsions employed were found to be effective as transporting candidates for the efficient release of hormones in the transdermal delivery of human sexual steroids.