Proinflammatory Cytokines Regulate LOX-1 Expression in Vascular Smooth Muscle Cells

Abstract

We suppose that upregulated LOX-1 expression in SMC of advanced atherosclerotic lesions is a response to these proinflammatory cytokines. Moreover, the proinflammatory effects of these cytokines can be decreased by the antiinflammatory effect of PPARgamma.