Novel Syntheses of Gabapentin <i>via</i> Addition of Hydrocyanic Acid to Cyclohexylidenemalonate or Cyano(cyclohexylidene)acetate

Abstract

Abstract Several synthetic pathways to the anticonvulsivum gabapentin (1‐(aminomethyl)cyclohexaneacetic acid) have been investigated. Advantages and drawbacks of the different routes are discussed, and the most economical and technically most feasible synthesis is pointed out.