Publication | Closed Access
Novel Syntheses of Gabapentin <i>via</i> Addition of Hydrocyanic Acid to Cyclohexylidenemalonate or Cyano(cyclohexylidene)acetate
23
Citations
2
References
1991
Year
Molecular PharmacologyInhibitory ActivityPharmaceutical ChemistryBioorganic ChemistryBiochemistryNovel SynthesesNatural SciencesMedicineDiversity-oriented SynthesisAnticonvulsivum GabapentinOrganic ChemistrySynthetic ChemistryCyclohexaneacetic AcidPharmacologyHydrocyanic AcidFeasible SynthesisNatural Product Synthesis
Abstract Several synthetic pathways to the anticonvulsivum gabapentin (1‐(aminomethyl)cyclohexaneacetic acid) have been investigated. Advantages and drawbacks of the different routes are discussed, and the most economical and technically most feasible synthesis is pointed out.
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