Identification of Growth-factor-inducible Genes in Mouse Fibroblasts

Abstract

It is well established that new mRNA synthesis in quiescent cells is required to respond to mitogens and to progress through G1 (for review, see Baserga 1985). The identification of genes and products that are involved in the response to growth factors will be essential not only for the understanding of cell proliferation, but also for several other normal processes governed by growth factors, including development, differentiation, and wound repair, that share common events such as cell proliferation and cell movement. The notion that some of these genes would encode nuclear proteins that could participate in the trans-activation of genes required for the progression through G1 is supported by the initial findings that the proto-oncogenes c-fos and c-myc present an immediate change in expression following stimulation of fibroblasts with growth factors (Kelly et al. 1983; Greenberg and Ziff 1984; Kruijer et al, 1984; Müller et al. 1984; Bravo et al....