Pain‐like behaviour and spinal changes in the monosodium iodoacetate model of osteoarthritis in <scp>C57Bl</scp>/6 mice

Abstract

Intra-articular MIA is associated with referred mechanical hypersensitivity and increased release of CGRP from primary afferent fibres in the dorsal horn where second-order neuron activation is associated with a microglial response. Antagonism of CGRP receptor activation provides a therapeutic avenue for the treatment of pain in OA.