Copper‐Mediated CC Cross‐Coupling Reaction of Monocarba‐<i>closo</i>‐dodecaborate Anion for the Synthesis of Functional Molecules

Abstract

New couple: A cross-coupling reaction at the carbon vertex of a monocarba-closo-dodecaborate has been developed to allow efficient introduction of various aryl groups and other sp2/sp-hybridized carbon centers. A copper(I) complex facilitated the coupling process with a wide range of electrophiles at room temperature. The reaction was used to prepare a series of C-arylated carborane anion derivatives (see picture; B green, C blue), some of which showed androgen-receptor binding activity and also mesogenic properties.