Optical Resolution of [2,2]Paracyclophanes by High‐Performance Liquid Chromatography on Tris(3,5‐dimethylphenylcarbamates) of Celllulos and Amylose

Abstract

Optical resolution of 22 [2,2]paracyclophane derivatives was examined by high‐performance liquid chromatography (HPLC) using tris(3,5‐dimethylphenylcarbamates) of cellulose and amylose as chiral stationary phases. Most compounds were completely separated into enantiomers at least on one of the stationary phases. The preparation of hte new cyclophane derivatives 10, 11, 12, 14, 16 , and 19 as wel as a new procedure for the synthesis of 4‐fluoro‐[2,2]paracyclophane ( 3 ) are described.