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Theranostic Radiopharmaceuticals Based on Gold Nanoparticles Labeled with <sup>177</sup>Lu and Conjugated to Peptides
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2015
Year
NanoparticlesEngineeringPeptide ScienceProtein NanoparticlesGold NanoparticlesTheranostic RadiopharmaceuticalsNanomedicineTheranosticsRadiopharmaceutical TherapyRadiation OncologyMolecular ImagingTumor TargetingPharmacologyBiomolecular EngineeringRadiopharmaceuticalsDrug Delivery SystemsMolecular Recognition AssessmentMedicineDifferent PeptidesDrug DiscoveryGold Nanoparticles Labeled
Gold nanoparticles (AuNPs) have been proposed for a variety of medical applications such as localized heat sources for cancer treatment and drug delivery systems. The conjugation of peptides to AuNPs produces stable multimeric systems with target-specific molecular recognition. Lutetium- 177 ((177)Lu) has been successfully used in peptide radionuclide therapy. Recently, (177)Lu-AuNPs conjugated to different peptides have been proposed as a new class of theranostic radiopharmaceuticals. These radioconjugates may function simultaneously as molecular imaging agents, radiotherapy systems and thermal-ablation systems. This article covers advancements in the design, synthesis, physicochemical characterization, molecular recognition assessment and preclinical therapeutic efficacy of gold nanoparticles radiolabeled with (177)Lu and conjugated to RGD (-Arg-Gly-Asp-), Lys(3)-Bombesin and Tat(49-57) peptides.