Antibacterial activity of crude extracts of Spirulina platensis and its structural elucidation of bioactive compound

Abstract

The concept of biological control for health maintenance has received widespread attention during the last few years. Therefore, the main objective of this work was to look for active substances that could be used as antibacterial agents. To achieve this target, two different extract (Methanol and Acetone) from Spirulina platensis was examined. The algal extracts were tested in vitro for their antibacterial effects against (Staphylococcus aureus, Salmonella typhimurium) using Agar well diffusion method and Paper disc diffusion method and concentration from 250 ppm up to 7000 ppm was taken and observed all these bacteria showed inhibition in growth by these extracts. During gas chromatography mass spectrometry (GC-MS) analysis it was observed that mostly fatty acid compounds are present in crude extract which are associated with the antibacterial properties.   Key words: Spirulina platensis, antibacterial activity, agar-well diffusion method, paper-disc diffusion method, gas chromatography-mass spectrometry (GC-MS) analysis.