Self‐Assembling Ligands for Multivalent Nanoscale Heparin Binding

Abstract

Supramolecular string of pearls: Polycationic ligands are designed to self-assemble into spherical pseudo-dendrimers that are capable of binding polyanionic heparin with affinities and binding modes similar to covalent nanostructures such as dendrimers and proteins (see picture; purple: heparin, red/blue: self-assembling ligand). Binding of the ligands to heparin induces nanoscale organization of the formed nanostructures. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.