Concepedia

Maternal HLA Homozygosity and Mother‐Child HLA Concordance Increase the Risk of Vertical Transmission of HIV‐1

Romel D. Mackelprang, Grace John‐Stewart, Mary Carrington, Barbra A. Richardson, Sarah Rowland‐Jones, Xiaojiang Gao, Dorothy Mbori‐Ngacha, Jennifer Mabuka, Barbara Lohman‐Payne, Carey Farquhar

The Journal of Infectious Diseases · 2008 · 72 citations · 19 references

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Abstract

The risks of overall, in utero, and breast milk HIV-1 transmission increased with HLA concordance and homozygosity. The increased risk may be due to reduced alloimmunity or less diverse protective immune responses.

References

19

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Kelly S. MacDonald, Joanne Embreé, Simon Njenga et al. · The Journal of Infectious Diseases · 1998 · 198 citations · Full text