Concepedia

Publication | Open Access

Histone H3 Glutathionylation in Proliferating Mammalian Cells Destabilizes Nucleosomal Structure

DOIFull Paper Access

105

Citations

45

References

2013

Year

Jose Luis García‐Giménez, Gloria Olaso‐González, Sandra B. Hake, Clemens Bönisch, Sonja M. Wiedemann, Jelena Marković, Amparo Gimeno, Carme Pérez-Quilis, Òscar Palacios, Mercè Capdevila,
Antioxidants and Redox Signaling

Abstract

Histone H3 senses cellular redox changes through glutathionylation of Cys, which increases during cell proliferation and decreases during aging. Glutathionylation of histone H3 affects nucleosome stability structure leading to a more open chromatin structure.

References

YearCitations

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