PubMed · 1974 · 56 citations · 0 references
MedicineNuclear MedicineRadiologyBone ScintigraphyDiagnostic ImagingDiagnostic RadiologyBone MetastasisBone Metastasis ImagingBone PathologyBone Tumor ImagingMetastatic Bone DiseaseTumor ImagingAseptic Bone NecrosisBone BiologyMetastatic Bone Disease DetectionRadiolucent LesionsRadionuclide Bone ImagingRadionuclide Uptake PatternsRadionuclide Uptake QuantificationScintigraphic Uptake Interpretation
“Cold” (photon-deficient) bone scan lesions are reported in seven patients with a variety of disease processes including metastatic disease, post-traumatic aseptic necrosis, and sickle cell-C crisis. Patients were studied with 99mTc-polyphosphate and/or 18F scans and in two cases, 111In-chloride bone marrow scans. Foci of decreased radioisotope activity were identified corresponding to sites of metastatic tumor and bone infarcts. Infarction may be a primary mechanism in the production of diminished radionuclide uptake in some of the cases. Consideration is given to a spectrum of abnormal bone-imaging manifestations (increased uptake, “normal” uptake, to photon-deficient) as a useful concept in the interpretation and understanding of bone scans.