Low-Dose Topical Delivery of All-<i>Trans</i> Retinoic Acid for Cervical Intraepithelial Neoplasia II and III

Abstract

Lower concentrations of atRA applied with a cervical cap for 4 days were no more effective than placebo. However, the rate of histologic regression in biopsied CIN II/III patients was high even over a short time interval, and emphasizes the importance of having a placebo arm and an adequate sample size.