Limited Therapeutic Effect of N‐Acetylcysteine on Hepatic Insulin Resistance in an Experimental Model of Alcohol‐Induced Steatohepatitis

Abstract

Antioxidant treatments reduce the severity of chronic alcohol-related steatohepatitis, possibly because of the decreased expression of inflammatory mediators and ceramide accumulation, but they do not restore insulin/IGF-1 signaling in liver, most likely due to persistent elevation of GM3 synthase expression. Effective treatment of alcohol-related steatohepatitis most likely requires dual targeting of oxidative stress and insulin/IGF resistance.