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Publication | Open Access

Role of Focal Adhesion Kinase in Regulating YB–1–Mediated Paclitaxel Resistance in Ovarian Cancer

DOIFull Paper Access

194

Citations

31

References

2013

Year

Yu Kang, Wei Hu, Cristina Ivan, Heather J. Dalton, Takahito Miyake, Chad V. Pecot, Behrouz Zand, Tao Liu, Jie Huang, Nicholas B. Jennings,
JNCI Journal of the National Cancer Institute

Abstract

We have identified a novel pathway whereby FAK inhibition with VS-6063 overcomes YB-1-mediated paclitaxel resistance by an AKT-dependent pathway. These findings have implications for clinical trials aimed at targeting FAK.

References

YearCitations

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