Interaction Between P450 Eicosanoids and Nitric Oxide in the Control of Arterial Tone in Mice

Abstract

Our data indicate that the EDHF response in mice is caused by hydrogen peroxide, but not by P450 eicosanoids. Moreover, P450 eicosanoids are vasodilatory, largely through their ability to activate endothelial NO synthase (eNOS) and NO release.