Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus

Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus.

H.‐H. TING, Farris K. Timimi, Kimberly Boles et al. · Journal of Clinical Investigation · 1996 · 873 citations · Full text

Medicine, Pharmacology, Physiology +14

Tetrahydrobiopterin restores endothelial function in hypercholesterolemia.

Erik S.G. Stroes, J Kastelein, Francesco Cosentino et al. · Journal of Clinical Investigation · 1997 · 587 citations · Full text

Medicine, Cardiology, Pharmacology +13

Oxidation of Tetrahydrobiopterin by Peroxynitrite: Implications for Vascular Endothelial Function

Sheldon Milstien, Zvonimir S. Katušić · Biochemical and Biophysical Research Communications · 1999 · 477 citations

Life Sciences, Biochemistry, Physiology +12

Abnormal biopterin metabolism is a major cause of impaired endothelium-dependent relaxation through nitric oxide/O2- imbalance in insulin-resistant rat aorta.

Kazuya Shinozaki, Atsunori Kashiwagi, Yoshihiko Nishio et al. · Diabetes · 1999 · 326 citations

Life Sciences, Endocrinology, Physiology +14

Acute Amelioration of Diabetic Endothelial Dysfunction with a Derivative of the Nitric Oxide Synthase Cofactor, Tetrahydrobiopterin

Galen M. Pieper · Journal of Cardiovascular Pharmacology · 1997 · 223 citations

Medicine, Pharmacology, Physiology +15