Laccase‐Mediated Deprotection of <i>para</i>‐Methoxyphenyl (PMP)‐Protected Amines

Abstract

Abstract A novel enzymatic procedure for the oxidative deprotection of p ‐methoxyphenyl (PMP)‐protected amines is described. By using laccases (E.C. 1.10.3.2) under mildly acidic conditions, a variety of PMP‐protected amines were successfully deprotected. The rate of deprotection was solvent‐ and pH‐dependent, and the reaction scope could be increased by using so‐called mediators.