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Chemical-induced chromosome damage
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0
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1969
Year
Control MaterialsDna DamageRat LeucocytesCytogeneticsGeneticsMolecular BiologyEpigeneticsToxicological MechanismOxidative StressHematologyToxicologyChemical-induced Chromosome DamageGenome InstabilityBiochemistryDevelopmental ToxicologyExperimental ToxicologyPharmacologyCell BiologyChromatinNatural SciencesMedicine
The development of methods for the investigation of chemical-induced chromosome damage is described using either bone marrow cells from rats and mice, or cultured rat leucocytes. The application of these methods to 4 biologically active compounds is demonstrated, and the value of such compounds as control materials for similar investigations is discussed.