Quality of Life Following Surgery for Anterior Skull Base Tumors

TLDR

The study assessed postoperative quality of life in patients who underwent anterior skull base tumor resection and sought to identify predictors of functional outcome. A retrospective survey of 69 patients who had subcranial tumor resection used a 39‑item, disease‑specific questionnaire covering six QOL domains, achieving a 98 % response rate. Overall, 74 % of patients reported stable or improved QOL within six months, yet malignancy, old age, comorbidity, wide resection, and radiotherapy were identified as negative prognostic factors, with financial status and emotional state most affected.

Abstract

To evaluate patients' quality of life (QOL) after surgical extirpation of anterior skull base tumors, to elucidate different QOL domains, and to define possible predictors of functional outcome postoperatively.Retrospective survey.University-affiliated medical center.Sixty-nine patients (76 consecutive cases) who underwent subcranial surgery between 1994 and 2002 for extirpation of anterior skull base tumors.A multidimensional, disease-specific questionnaire with 39 items was used. Six relevant domains of QOL were assessed: role of performance, physical functioning, vitality, pain, specific symptoms, and impact on emotions.The response rate for completing the questionnaire was 98% (40/41) after excluding patients who died (n = 13), were lost to follow-up (n = 10), and were operated on within 3 months of commencement of the study (n = 5). Thirty patients (74%) reported a significant improvement or no change in overall QOL within 6 months after surgery. The worst impact of surgery on the patients' QOL was on their financial status and emotional state. The most influential factor on QOL was malignancy leading to a significant decrease in the overall score. Radiotherapy, old age, comorbidity, and wide resection also significantly worsened QOL scores of specific domains.After subcranial extirpation of anterior skull base tumors, the overall outcome of the patients is good. Old age, malignancy, comorbidity, wide resection, and radiotherapy are negative prognostic factors for these patients' QOL.