Oxidized Titanium Implants Enhance Osseointegration via Mechanisms Involving<scp>RANK</scp>/<scp>RANKL</scp>/<scp>OPG</scp>Regulation

Abstract

The present results show that oxidized implants rapidly promote a high degree of mineralized bone apposition to the surface. As determined by the gene expression data, the mechanisms involve an early induction of osteoclastic differentiation and subsequently more intensive bone remodeling, which accelerates the maturation of the bone-implant interface. The present study suggests that the RANKL/OPG ratio is a sensitive indicator for monitoring the remodeling process during osseointegration.