Enantioselective Synthesis of Quaternary Carbon Stereogenic Centers through Copper‐Catalyzed Conjugate Additions of Aryl‐ and Alkylaluminum Reagents to Acyclic Trisubstituted Enones

Abstract

Acyclic quaternary carbons by conjugate addition: The first examples of catalytic enantioselective conjugate additions of aryl and alkyl units that generate acyclic all-carbon quaternary stereogenic centers have been developed (see scheme). The requisite organoaluminum reagents can either be prepared in situ from easily available organolithiums or purchased at low cost.