Serial Expression of Hypoxia Inducible Factor-1α and Neuronal Apoptosis in Hippocampus of Rats with Chronic Ischemic Brain

Abstract

This study showed that BCAO induces acute ischemic responses for about 4 weeks then chronic ischemia in the hippocampus. These in vivo data are the first to show the temporal sequence of apoptosis and HIF-1α expression.