Elevated Expression of APE1/Ref-1 and its Regulation on IL-6 and IL-8 in Bone Marrow Stromal Cells of Multiple Myeloma

The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice.

Steven Xanthoudakis, Richard J. Smeyne, J. Wallace et al. · Proceedings of the National Academy of Sciences · 1996 · 509 citations · Full text

Life Sciences, Developmental Biology, Molecular Biology +16

Bone marrow mesenchymal stem cells are abnormal in multiple myeloma

Jill Corre, Karène Mahtouk, Michel Attal et al. · Leukemia · 2007 · 321 citations · Full text

Medicine, Cell Biology, Hematology +14

APE1/Ref-1 Interacts with NPM1 within Nucleoli and Plays a Role in the rRNA Quality Control Process

Carlo Vascotto, Damiano Fantini, Milena Romanello et al. · Molecular and Cellular Biology · 2009 · 242 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

APE1 overexpression is associated with cisplatin resistance in non-small cell lung cancer and targeted inhibition of APE1 enhances the activity of cisplatin in A549 cells

Dong Wang, Xueqin Yang, Liansheng Chen et al. · Lung Cancer · 2009 · 191 citations

Medicine, Oncology, Pharmacology +9

Hyperactivated NF-κB and AP-1 Transcription Factors Promote Highly Accessible Chromatin and Constitutive Transcription across the Interleukin-6 Gene Promoter in Metastatic Breast Cancer Cells

Matladi N. Ndlovu, Carine Van Lint, Karlien Van Wesemael et al. · Molecular and Cellular Biology · 2009 · 157 citations · Full text

Medicine, Cancer Biology, Oncology +17