4-(Dimethylamino)pyridine-catalysed iodolactonisation of γ,δ-unsaturated carboxylic acids

Abstract

4-(Dimethylamino)pyridine functioned as an excellent catalyst for iodolactonisation reactions of γ,δ-unsaturated carboxylic acids, affording γ-lactones, δ-lactones, or both under neutral conditions at room temperature. The effects of substrate structures on the iodolactonisation were investigated, and a catalytic mechanism is proposed.