Chemical Communications · 2014 · 45 citations · 20 references
Life SciencesBiochemistryCell BiologyCellular MetabolismMitochondrial BiologyMitochondrial BiochemistryMitochondrial BioenergeticsMitochondrial FunctionMitochondrial MembranesMitochondrial MetabolismMitochondrial PhysiologyFluorescent Probe DesignFluorescent ProbesMitochondrial Respiration ControlMitochondrial Respiration InhibitionMitochondrial Respiratory ComplexesMitochondrial TargetsOxidative Phosphorylation UncouplingUncoupling Proteins
Linking decyl-triphenyl-phosphonium to fluorescein yields a fluorescent probe that accumulates in energized mitochondria, facilitates proton transfer across membranes and stimulates mitochondrial respiration. This features a mitochondria-targeted uncoupler, being of potential interest for therapeutic use against oxidative stress-related diseases.
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Fluorescent probes for sensing and imaging
Tasuku Ueno, Tetsuo Nagano · Nature Methods · 2011 · 629 citations
Mechanism of Coupling of Oxidative Phosphorylation and the Membrane Potential of Mitochondria
E.A. Liberman, V. P. Topaly, L. M. Tsofina et al. · Nature · 1969 · 491 citations