Measurement of the Distribution Volume of Gadopentetate Dimeglumine at Echo-planar MR Imaging to Quantify Myocardial Infarction: Comparison with^99mTc-DTPA Autoradiography in Rats

Abstract

The fractional distribution volumes of gadopentetate dimeglumine and 99mTc-DTPA are similar and indicate extracellular distribution in normal myocardium and intracellular as well as extracellular distribution in reperfused infarction. Because the failure of cells to exclude these agents is indicative of necrosis, contrast medium-enhanced MR imaging may be useful to quantify myocardial infarction.