Phytotherapy Research · 1990 · 47 citations · 3 references
MedicineMedicinal ChemistryPharmacologyDrug DiscoveryEthnobotanyStructure-activity RelationshipsAntiparasitic AgentsAntiparasitic PharmacologyMalariaMedicinal Plant KnowledgeMedicinal PlantsAntimalarial AgentsAntimalarial ChemotherapyAntimalarial Drug DevelopmentBotanical BioassaysMedicinal HerbsPlasmodium FalciparumTraditional Herbal MedicineTreatment Of Malaria
Abstract Artemisia abrotanum L. (Compositae) is widely used in European herbal medicine for treatment of various ailments including fever. Crude extracts of this plant and some of their constituents were tested for antimalarial activity against Plasmodium falciparum in vitro using the technique of [ 3 H]hypoxanthine incorporation. Two pure compounds, isofraxidin and a novel sesquiterpene, 1(S*)‐hydroxy‐α‐bisabololoxide A acetate were found to be active (IC 50 values of 7.95 and 5.09 m̈g/mL, respectively).
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