APC and CTNNB1 Mutations in a Large Series of Sporadic Colorectal Carcinomas Stratified by the Microsatellite Instability Status

Abstract

This study confirms that APC mutations are less frequent in MSI-H tumours than in MSS and MSI-L tumours. However, CTNNB1 mutations do not substitute for APC mutations in MSI-H tumours in these Norwegian patients.