Highly regioselective synthesis of 1,7-diprotected 1,4,7,10-tetraazacyclododecane derivatives

Abstract

Reaction of dimethylformamicle diethyl acetal with monoalkylated 1,4,7,10-tetraazacyclododecane derivatives 3, followed by hydrolysis of the tricyclic intermediates 4, selectively affords 1,7-disubstituted tetraazamacrocycles 5.