CONCERNING THE EFFECTS OF MAGNESIUM SULFATE ON RENAL FUNCTION, ELECTROLYTE EXCRETION, AND CLEARANCE OF MAGNESIUM 1

Abstract

The effect of the parenteral administration of magnesium sulfate on the renal hemodynamics of normal dogs (1) and normal children (2) has been previously reported. However, no data are available concerning the effects of magnesium sulfate on the excretion of other electrolytes, nor have studies on the renal clearance of magnesium been reported. It is the purpose of this report to present such data. METHODS Studies of renal function, electrolyte excretion, and the clearance of magnesium were performed on six young men without evidence of cardiovascular or renal disease. The experimental subjects received a normal hospital diet which contained between 7 and 15 grams of sodium