Controlled Assembly of Macromolecular β‐Sheet Fibrils

Abstract

Blocking out aggregation: Triblock copolymers consisting of a central β-sheet polypeptide block with the repeating [(AlaGly)3GluGly]n sequence and poly(ethylene glycol) (PEG) of Mn=750 g mol−1 were prepared and the assembly properties in the solid state were investigated. Attachment of PEG prevented the macroscopic aggregation of the β-sheet polypeptide portion and, instead, resulted in the formation of well-defined fibrils. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z462415_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.