Haplotype Analysis Confirms the Association Between the <i>HCRTR2</i> Gene and Cluster Headache

Abstract

Our data confirm previous studies suggesting that the HCRTR2 gene or a linked locus significantly modulates the risk for CH. In addition, we suggest that the V308I substitution of the HCRTR2 may interfere with the dimerization process of the receptor, thereby influencing its functional activity.