Characterization of Genetically Modified T-Cell Receptors that Recognize the CEA:691-699 Peptide in the Context of HLA-A2.1 on Human Colorectal Cancer Cells - Concepedia

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Characterization of Genetically Modified T-Cell Receptors that Recognize the CEA:691-699 Peptide in the Context of HLA-A2.1 on Human Colorectal Cancer Cells

DOI Full Paper Access

119

Citations

42

References

2008

Year

Maria R. Parkhurst, Jayne Joo, John P. Riley, Zhiya Yu, Yong Li, Paul F. Robbins, Steven A. Rosenberg

Clinical Cancer Research

Abstract

The modified CEA-reactive TCRs are good candidates for future gene therapy clinical trials and show the power of selected amino acid substitutions in the antigen-binding regions of the TCR to enhance desired reactivities.

References

	Year	Citations

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