The Crabtree Effect and its Relation to the Petite Mutation

Abstract

SUMMARY: Some yeast strains are able to give rise to “petite” mutants upon treatment with euflavine while some other strains do not give rise to cytoplasmic respiration-deficient mutants. Nevertheless euflavine mimics the effect of the petite mutation in those strains which are unable to give petite mutants. There is a correlation between the presence of the Crabtree effect in a yeast strain and its ability to give petite mutants.