L-carnosine inhibits high-glucose-mediated matrix accumulation in human mesangial cells by interfering with TGF- production and signalling

Abstract

L-carnosine can modulate matrix accumulation in two ways. Firstly, inhibition of TGF-β production might result in an overall inhibition of matrix accumulation and secondly, L-carnosine inhibits TGF-β-induced matrix accumulation, most likely via inhibition of the ALK5 pathway.