Sensors · 2015 · 28 citations · 34 references
EngineeringBioengineeringBiomedical EngineeringBiosensorsMicroelectromechanical SystemsSensorsImplantable BiosensorsImplantable MicrodevicesImplantable Neural DevicesNeural Signal AcquisitionWearable BiosensorsWireless Power TransferEffective CoverageImplantable Wireless Power TransferInductive CouplingNeural RecordingReal-time MonitoringWearable Neural SensorsWireless Neural RecordingWireless Sensing
In this paper, we report a power management system for autonomous and real-time monitoring of the neurotransmitter L-glutamate (L-Glu). A low-power, low-noise, and high-gain recording module was designed to acquire signal from an implantable flexible L-Glu sensor fabricated by micro-electro-mechanical system (MEMS)-based processes. The wearable recording module was wirelessly powered through inductive coupling transmitter antennas. Lateral and angular misalignments of the receiver antennas were resolved by using a multi-transmitter antenna configuration. The effective coverage, over which the recording module functioned properly, was improved with the use of in-phase transmitter antennas. Experimental results showed that the recording system was capable of operating continuously at distances of 4 cm, 7 cm and 10 cm. The wireless power management system reduced the weight of the recording module, eliminated human intervention and enabled animal experimentation for extended durations.
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Glutamate neurotoxicity and diseases of the nervous system
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