A double‐blind, placebo‐controlled pilot study of quetiapine for depressed adolescents with bipolar disorder

Abstract

The results suggest that quetiapine monotherapy is no more effective than placebo for the treatment of depression in adolescents with bipolar disorder. However, limitations of the study, including the high placebo response rate, may have contributed to our findings and should be considered in the design of future investigations of pharmacological interventions for this population.