Subacute Effusive-Constrictive Pericarditis

TLDR

Effusive‑constrictive pericarditis is a distinct compressive pericardial disease observed in 13 patients, often idiopathic or post‑radiotherapy, characterized by an effusion into a free pericardial space with constriction, and distinguished by enlarged heart shadow, paradoxical pulse, systolic dip in venous pressure, and absence of atrial fibrillation. The study emphasizes using pressure measurements during combined cardiac catheterization and pericardiocentesis to differentiate effusive‑constrictive pericarditis from cardiac tamponade without constriction. Four patients progressed to noneffusive constrictive pericarditis, medical therapy such as corticosteroids and pericardiocentesis offered limited benefit, whereas surgical intervention generally produced satisfactory results.

Abstract

Clinical and hemodynamic observations are reported in 13 patients who demonstrated a distinct pathophysiologic form of compressive pericardial disease characterized by effusion into a free pericardial space associated with constriction of the heart by the visceral pericardium. The pericardial disease was idiopathic (nine patients) or subsequent to radiotherapy (four patients), with a maximal duration of symptoms of 16 months. Enlarged heart shadow, prominent paradoxical pulse, predominant systolic dip in the venous pressure pulse, and absence of atrial fibrillation were features that tended to distinguish the effusive-constrictive cases from those with noneffusive chronic constrictive pericarditis. The value of pressure measurements during combined cardiac catheterization and pericardiocentesis is emphasized in the differentiation of effusive-constrictive pericarditis from cardiac tamponade without constriction. Four patients were observed to progress through an effusive-constrictive phase to noneffusive constrictive pericarditis. Corticosteroids, pericardiocentesis, and other medical therapy produced some benefit but did not relieve constriction. The results of surgery were generally satisfactory.