Erythropoietin for Neuroprotection in Neonatal Encephalopathy: Safety and Pharmacokinetics

Abstract

Epo 1000 U/kg per dose intravenously given in conjunction with hypothermia is well tolerated and produces plasma concentrations that are neuroprotective in animals. A large efficacy trial is needed to determine whether Epo add-on therapy further improves outcome in infants undergoing hypothermia for HIE.