Agonists of peroxisome-proliferator activated receptor-alpha (clofibrate and WY14643) reduce renal ischemia/reperfusion injury in the rat. - Concepedia

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Agonists of peroxisome-proliferator activated receptor-alpha (clofibrate and WY14643) reduce renal ischemia/reperfusion injury in the rat.

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References

2002

Year

Ahila Sivarajah, Prabal K. Chatterjee, Yoshiyuki Hattori, Paul Aj. Brown, Keith N. Stewart, Zoran Todorović, Hélder Mota‐Filipe, Christoph Thiemermann

Abstract

We show here that (i) renal I/R results in the down-regulation of PPAR-alpha in the kidney, and (ii) that the PPAR-alpha agonists clofibrate and WY14643 reduce the renal dysfunction and injury associated with I/R of the kidney.