Organic Solvent Nanofiltration‐Supported Purification of Organocatalysts

Abstract

Abstract In this study, the successful use of organic solvent nanofiltration for the purification of three highly enantioselective quinine‐based organocatalysts was demonstrated. Commercially available solvent‐resistant membranes (DuraMem series) were utilized to remove specific impurities that originated from their respective synthesis pathways. DuraMem 200 exhibited the highest catalyst retention of 99 %, which facilitated catalyst purification at the gram scale with a purity >99 %.