Spectrophotometric Determination of Diclofenac Sodium in Gel-Ointment

Abstract

Abstract A direct spectrophotometric method has been developed for quantitative determination of Diclofenac Sodium in gel-ointments. The reported technique does not require a separation step and it is based on only one extraction of Diclofenac Sodium from the gel-ointment and measurement of the absorbance at two wavelengths. This procedure allows also indirect quantitative determination of degradation products due to indolinone cyclization. The method is rapid, simple, specific, reproducible and stability indicating. Key Words: SpectrophotometryDiclofenac Sodium determinationGel-Ointment