Evidence of cell damage in rat salivary glands after isoproterenol

Abstract

Abstract Isoproterenol, which stimulates cell replication in rat salivary gland acinar cells also produces cytoplasmic disruption in these cells, although there is apparently little resultant cell death. Evidence of cell damage includes loss of cytoplasmic density, vesiculation of endoplasmic reticulum, appearance of large lipid droplets within cells, and invasion of the epithelium by lymphoid elements.