Publication | Closed Access
An alternative methodology for imputing missing data in trials with genotype-by-environment interaction
13
Citations
13
References
2012
Year
Haplotype DeterminationGenetic TestingGenotype-phenotype AssociationAlternative MethodologyGenetic EpidemiologyGenotype-by-environment InteractionMulti-environment Trials ArisesStatistical GeneticsGabriel Cross-validation MethodRandomized Controlled TrialBiostatisticsSingular Value DecompositionPublic HealthPopulation GeneticsStatisticsEpidemiologyGenetic Predisposition
A common problem in multi-environment trials arises when some genotype-by-environment combinations are missing. The aim of this paper is to propose a new deterministic imputation algorithm using a modification of the Gabriel cross-validation method. The method involves the singular value decomposition (SVD) of a matrix and was tested using three alternative component choices of the SVD in simulations based on two complete sets of real data, with values deleted randomly at different rates. The quality of the imputations was evaluated using the correlations and the mean square deviations between these estimates and the true observed values. The proposed methodology does not make any distributional or structural assumptions and does not have any restrictions regarding the pattern or mechanism of the missing data.
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