Hydrogen Peroxide Potentiates the EDHF Phenomenon by Promoting Endothelial Ca ²⁺ Mobilization

Abstract

H(2)O(2) can enhance EDHF-type relaxations by potentiating Ca(2+) release from endothelial stores, probably via redox modification of the InsP(3) receptor, leading to the opening of hyperpolarizing endothelial K(Ca) channels and an electrotonically-mediated relaxant response.