Preclinical safety evaluation of cerivastatin, a novel HMG-CoA reductase inhibitor

Lovastatin decreases coenzyme Q levels in humans.

Karl Folkers, Peter H. Langsjoen, Richard A. Willis et al. · Proceedings of the National Academy of Sciences · 1990 · 427 citations

Life Sciences, Biochemistry, Pharmacology +16

Myopathy and Rhabdomyolysis Associated With Lovastatin-Gemfibrozil Combination Therapy

L. Ross Pierce · JAMA · 1990 · 419 citations

Medicine, Internal Medicine, Pharmacotherapy +9

Evidence of Plasma CoQ10‐Lowering Effect by HMG‐CoA Reductase Inhibitors: A Double‐Blind, Placebo‐Controlled Study

Giovanni Ghirlanda, A. Oradei, Andrea Manto et al. · The Journal of Clinical Pharmacology · 1993 · 327 citations

Medicine, Pharmacology, Pharmacotherapy +11

Decreases in serum ubiquinone concentrations do not result in reduced levels in muscle tissue during short-term simvastatin treatment in humans*

Reijo Laaksonen, Kalle Jokelainen, Timo Sahi et al. · Clinical Pharmacology & Therapeutics · 1995 · 177 citations

Life Sciences, Biochemistry, Pharmacotherapy +17

HMG-CoA reductase inhibitor-induced myopathy in the rat: cyclosporine A interaction and mechanism studies.

Peter F. Smith, R. S. Eydelloth, Scott Grossman et al. · Journal of Pharmacology and Experimental Therapeutics · 1991 · 147 citations

Medicine, Pharmacology, Pharmacotherapy +13