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Identification of stable S-adenosylmethionine (SAM) analogues derivatised with bioorthogonal tags: effect of ligands on the affinity of the E. colimethionine repressor, MetJ, for its operator DNA

Catherine Joce, Jamie A. Caryl, Peter G. Stockley, Stuart L. Warriner, Adam Nelson

Organic & Biomolecular Chemistry · 2008 · 19 citations · 18 references

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Abstract

The efficient synthesis of a range of stable SAM mimetics, and their ability to promote the binding of the E. coli methionine repressor (MetJ) to its operator DNA, is described.

References

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