Journal of the Brazilian Chemical Society · 2005 · 74 citations · 0 references
Life SciencesBotanyPlant SciencesMycologyPlant BiochemistryPlant-microbe InteractionsFungal BiochemistryFungal MetabolismFungal Natural Product BiosynthesisFungal Secondary MetabolitesPlant-pathogenic FungiBioactive Fungal MetabolitesEndophytic Fungal MetabolitesFungal Bioactive CompoundsFungal Metabolite BiosynthesisMass Spectral Data AnalysisPlant-associated Fungal MetabolitesSecondary MetabolitesStructure Elucidation Of Fungal Metabolites
Two new metabolites, ethyl 2,4-dihydroxy-5,6-dimethylbenzoate (1) and phomopsilactone (2) were isolated from Phomopsis cassiae, an endophytic fungus in Cassia spectabilis. Their structures were elucidated by 1D and 2D NMR, MS and IR spectral data. Compounds 1 and 2 displayed strong antifungal activity against the phytopatogenic fungi Cladosporium cladosporioides and C. sphaerospermum, as well as cytotoxicity against human cervical tumor cell line (HeLa), in in vitro assays.